TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function
Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen, Caitlin R. Hopkins, Geoffrey T. Rouin, Hua Huang, Weimin Kong, Christopher Holliday, Volker Wiebking, Robert L. Bartoszek, Sydney Drury, Katherine Dalton, O. M. Koucky, Zeyu Chen, Josephine Ruth Giles, , Joseph A. Fraietta
This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.
Science Advances · Nov 13, 2024Peer-reviewedImmunology