Author

R. M. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:CITE-seq· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. L. Levine· 2 shared E. J. Wherry· 2 shared F. D. Bushman· 2 shared G. M. Chen· 2 shared J. A. Fraietta· 2 shared J. J. Melenhorst· 2 shared N. V. Frey· 2 shared A. Bolomsky· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

B. L. Levine

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

A. J. Dimitri, A. E. Baxter, G. M. Chen, C. R. Hopkins, G. T. Rouin, H. Huang, W. Kong, C. H. Holliday, V. Wiebking, R. Bartoszek, S. Drury, K. Dalton, O. M. Koucky, Z. Chen, J. R. Giles, , J. A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

bioRxiv · Mar 29, 2024Immunology

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Y. Yang, T. Oellerich, P. Chen, A. Bolomsky, M. Ceribelli, B. Haupl, G. W. Wright, J. D. Phelan, D. W. Huang, J. W. Lord, C. K. Van Winkle, X. Yu, J. Wisnieski, J. Q. Wang, F. A. Tosto, , R. M. Young

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

bioRxiv · Nov 28, 2021Cancer Biology

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

J. J. Melenhorst, G. M. Chen, M. Wang, D. . L. Porter, P. Gao, S. Bandyopadhyay, I. Pruteanu-Malinici, C. L. Nobles, S. Maji, N. V. Frey, S. I. Gill, L. Tian, I. Kulikovskaya, M. Gupta, M. M. Davis, , C. H. June

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

bioRxiv · May 7, 2021 · PreprintImmunology

Uncovering the core microbiome and distributions of palmerolide in Synoicum adareanum across the Anvers Island archipelago, Antarctica

A. E. Murray, N. E. Avalon, L. Bishop, K. W. Davenport, E. Delage, A. E. K. Dichosa, D. Eveillard, M. L. Higham, S. Kokkaliari, C.-C. Lo, C. S. Riesenfeld, R. M. Young, P. S. G. Chain, B. J. Baker

This study examines the microbiome of Synoicum adareanum across Anvers Island, finding a core microbiome associated with palmerolide A production.

Marine Drugs · Jun 2, 2020Peer-reviewedMicrobiology