A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1
M. Saluri, A. Leppert, G. V. Gese, C. Sahin, D. Lama, M. Kaldmae, G. Chen, A. Elofsson, T. M. Allison, M. Arsenian-Henriksson, D. P. Lane, J. Johansson, B. M. Hallberg, M. Landreh
The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.
bioRxiv · Sep 29, 2022 · PreprintBiophysics