A. Elofsson

Structural Host-Virus Interactome Profiling of Intact Infected Cells

This study introduces SHVIP, a method to identify virus-host PPIs in intact infected cells, revealing 739 PPIs and validating their biological relevance through disruption experiments.

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

The paper uses AlphaFold-Multimer to predict a pentameric complex involved in mammalian egg-sperm fusion, including TMEM81, a previously uncharacterized sperm protein.

Enhancing Inter-link Coverage in Cross-Linking Mass Spectrometry through Context-Sensitive Subgrouping and Decoy Fusion

The paper improves inter-link detection in cross-linking mass spectrometry by using a fused database and context-sensitive subgrouping, increasing coverage by 30-75% while maintaining low error rates.

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

Multiplexed selectivity screening of anti-GPCR antibodies

The paper screens 400 anti-GPCR antibodies for selectivity using a multiplexed immunoassay against 215 solubilized GPCRs, finding 61% are selective, 11% bind off-target, and 28% bind none.

Insights into the structure-function relationship of the NorQ/NorD chaperones from Paracoccus denitrificans reveal shared principles of interacting MoxR AAA+/VWA domain proteins

This study investigates the structure-function relationship of NorQ/NorD chaperones in Paracoccus denitrificans, revealing shared mechanisms in MoxR/VWA domain protein interactions.

A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1

The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.

Complementing machine learning-based structure predictions with native mass spectrometry

This study shows that native mass spectrometry can reveal structural features not detectable by AlphaFold2, improving the accuracy of protein structure models.

A structural biology community assessment of AlphaFold 2 applications

This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.

Intra-helical salt bridge contribution to membrane protein insertion

This study investigates intra-helical salt bridges in transmembrane helices and finds they contribute to membrane insertion energy.

The Use of GC-, Codon-, and Amino Acid-frequencies to Understand the Evolutionary Forces at a Genomic Scale.

The paper analyzes amino acid frequency deviations from expected GC content to identify selective pressures across three kingdoms of life.

High GC Content Causes De Novo Created Proteins to be Intrinsically Disordered

The paper shows that GC content influences the structural properties of de novo proteins, explaining differences in disorder between yeast and Drosophila.