Author

B. M. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

C. J. Jackson· 2 shared A. F. Francisco· 1 shared A. M. Damry· 1 shared A. O. Hinton· 1 shared C. W. Ang· 1 shared D. Matthews· 1 shared J. M. Kelly· 1 shared J. Saunders· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

C. J. Jackson

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Author profile →

2 papers

Recent·Most cited

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

V. Vongsouthi, R. Georgelin, D. Matthews, J. Saunders, B. M. Lee, J. Ton, A. M. Damry, R. Frkic, M. A. Spence, C. J. Jackson

This study uses ancestral sequence reconstruction to explore PET-degrading cutinase sequence space, revealing diverse evolutionary pathways and the effectiveness of LASE in mapping fitness landscapes.

bioRxiv · Apr 25, 2024Biochemistry

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

C. W. Ang, B. M. Lee, C. J. Jackson, Y. Wang, S. G. Franzblau, A. F. Francisco, J. M. Kelly, P. V. Bernhardt, L. Tan, N. P. West, M. L. Sykes, A. O. Hinton, R. Bolisetti, V. M. Avery, M. A. Cooper, M. Blaskovich

This paper evaluates nitroimidazopyrazinone derivatives for antitubercular and antiparasitic activity, showing selectivity against M. tuberculosis and efficacy against T. cruzi in mouse models.

Journal of Medicinal Chemistry · Oct 13, 2022Peer-reviewedPharmacology & Toxicology