Author

B. M. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

B. Jones· 2 shared J. Minnion· 2 shared S. R. Bloom· 2 shared T. M. Tan· 2 shared A. M. Alonso· 1 shared A. Roberts· 1 shared A. Tomas· 1 shared B. Hansen· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

B. Jones

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

K. Suba, Y. Patel, A. M. Alonso, A. Roberts, B. Hansen, M. Norton, J. Shrewsbury, R. Kwok, V. Kalogianni, S. Chen, X. Liu, G. A. Rutter, B. Jones, J. Minnion, B. M. Owen, , V. Salem

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

bioRxiv · Sep 1, 2022 · PreprintPhysiology

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

P. Pickford, M. Lucey, R.-M. Rujan, E. R. McGlone, S. Bitsi, F. Ashford, I. R. Correa, D. Hodson, A. Tomas, G. Deganutti, C. A. Reynolds, B. M. Owen, T. M. Tan, J. Minnion, S. R. Bloom, B. Jones

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

bioRxiv · Mar 2, 2021Pharmacology & Toxicology

Convergent evolution between PALI1 and JARID2 for the allosteric activation of PRC2

Q. Zhang, S. C. Agius, S. F. Flanigan, V. Levina, B. M. Owen, C. Davidovich

This study shows that PALI1, a vertebrate-specific PRC2 accessory subunit, convergently evolved to function like JARID2 by allosterically activating PRC2 through methylation and DNA binding.

bioRxiv · May 28, 2020Biochemistry