Author

F. Ashford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Tomas· 2 shared D. Hodson· 2 shared S. Bitsi· 2 shared A. F. Cunningham· 1 shared A. Jasiulewicz· 1 shared A. Richter· 1 shared B. Jones· 1 shared B. M. Owen· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Tomas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Different vaccine platforms result in distinct antibody responses to the same antigen in haemodialysis patients

N. Wall, R. Lamerton, F. Ashford, M. Perez-Toledo, A. Jasiulewicz, G. Banham, M. L. Newby, S. E. Faustini, A. Richter, H. Selvaskandan, R. Billany, S. Adenwalla, I. R. Henderson, M. Crispin, M. Graham-Brown, , A. F. Cunningham

This study compares antibody responses in haemodialysis patients after vaccination with different platforms, finding mRNA vaccines induce better functional responses than viral vectors.

bioRxiv · Jan 14, 2024 · PreprintImmunology

Cysteine post-translational modifications regulate protein interactions of caveolin-3

F. Ashford, E. Brown, S. Calaghan, I. Jayasinghe, C. Henderson, W. Fuller, K. Wypijewski

This study identifies cysteine post-translational modifications in caveolin-3 that regulate its protein interactions and structural properties in muscle cells.

bioRxiv · Sep 15, 2022Cell Biology

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

P. Pickford, M. Lucey, R.-M. Rujan, E. R. McGlone, S. Bitsi, F. Ashford, I. R. Correa, D. Hodson, A. Tomas, G. Deganutti, C. A. Reynolds, B. M. Owen, T. M. Tan, J. Minnion, S. R. Bloom, B. Jones

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

bioRxiv · Mar 2, 2021Pharmacology & Toxicology

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells

W. Xu, F. Ashford, S. Bitsi, L. Schiffer, F. Qadir, W. Arlt, A. Tomas, D. Hodson, F. Mauvais-Jarvis

This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.

bioRxiv · May 12, 2020 · PreprintPhysiology