Author

R. Kwok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Covarrubias· 1 shared A. Kale· 1 shared A. M. Alonso· 1 shared A. Oliveira Pisco· 1 shared A. Roberts· 1 shared B. Hansen· 1 shared B. Jones· 1 shared B. M. Owen· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. J. Covarrubias

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2 papers

Recent·Most cited

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

K. Suba, Y. Patel, A. M. Alonso, A. Roberts, B. Hansen, M. Norton, J. Shrewsbury, R. Kwok, V. Kalogianni, S. Chen, X. Liu, G. A. Rutter, B. Jones, J. Minnion, B. M. Owen, , V. Salem

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

bioRxiv · Sep 1, 2022 · PreprintPhysiology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology