Author

B. MacTavish

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Kojetin· 2 shared A. A. Deniz· 1 shared C. C. Williams· 1 shared D. Scholl· 1 shared D. Zhu· 1 shared E. Kalkhoven· 1 shared J. Bass· 1 shared J. Li· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

D. Kojetin

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2 papers

Recent·Most cited

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

B. MacTavish, D. Zhu, J. Shang, Q. Shao, Z. Yang, T. Kamenecka, D. Kojetin

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

bioRxiv · Apr 23, 2024Biophysics

Structural basis of interdomain communication in PPARγ

S. A. Mosure, P. Munoz-Tello, K.-T. Kuo, B. MacTavish, X. Yu, D. Scholl, C. C. Williams, T. S. Strutzenberg, J. Li, J. Bass, R. Brust, E. Kalkhoven, A. A. Deniz, P. R. Griffin, D. Kojetin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

bioRxiv · Jul 13, 2022 · PreprintBiophysics