Author

E. Kalkhoven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. A. Deniz· 1 shared A. Borgman· 1 shared B. M. Faltas· 1 shared B. MacTavish· 1 shared C. C. Williams· 1 shared C. Shale· 1 shared D. Kojetin· 1 shared D. Scholl· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. A. Deniz

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Author profile →

2 papers

Recent·Most cited

Structural basis of interdomain communication in PPARγ

S. A. Mosure, P. Munoz-Tello, K.-T. Kuo, B. MacTavish, X. Yu, D. Scholl, C. C. Williams, T. S. Strutzenberg, J. Li, J. Bass, R. Brust, E. Kalkhoven, A. A. Deniz, P. R. Griffin, D. Kojetin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

bioRxiv · Jul 13, 2022 · PreprintBiophysics

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

J. Vlaar, A. Borgman, E. Kalkhoven, D. Westland, N. Besselink, C. Shale, B. M. Faltas, P. Priestley, E. Kuijk, E. Cuppen

This study identifies AHR{Delta}e8-9 as a novel driver mutation in urinary tract cancer, leading to ligand-independent pathway activation and tumorigenic properties in bladder organoids.

bioRxiv · Nov 9, 2021Cancer Biology