Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis.
B. Muralikrishnan, L. K. Edison, A. Dusthackeer, J. G. Reji, R. Ramachandran, A. Madhavan, R. Ajay Kumar
This study identifies chrysomycin A as an inhibitor of topoisomerase I in Mycobacterium tuberculosis, showing bactericidal activity and synergy with existing anti-TB drugs.
bioRxiv · Jun 23, 2021Biochemistry