Author

B. O. Diekman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. E. Copp· 2 shared S. Chubinskaya· 2 shared A. Hickey· 1 shared E. C. Warren· 1 shared E. L. Doherty· 1 shared G. A. Sessions· 1 shared G. Krohn· 1 shared H. L. Brown· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

M. E. Copp

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

M. E. Copp, J. Shine, H. L. Brown, K. R. Nimmala, S. Chubinskaya, J. A. Collins, R. Loeser, B. O. Diekman

This study shows that SIRT6 activation improves DNA repair efficiency in aging chondrocytes, reducing DNA damage in both human and mouse models.

bioRxiv · Feb 27, 2023 · PreprintCell Biology

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

E. L. Doherty, W. Y. Aw, E. C. Warren, M. Hockenberry, G. Krohn, S. D. Howell, B. O. Diekman, W. R. Legant, H. T. Nia, A. Hickey, W. J. Polacheck

The paper shows that COL3A1 mutations alter ECM composition and mechanical properties, affecting endothelial cell migration and suggesting ECM mechanics as a prognostic indicator for vEDS.

bioRxiv · Oct 16, 2022Bioengineering

The combination of mitogenic stimulation and cell cycle arrest induces senescence in equine and human cartilage explants

M. E. Copp, M. C. Flanders, R. Gagliardi, J. M. Gilbertie, G. A. Sessions, S. Chubinskaya, R. F. Loeser, L. V. Schnabel, B. O. Diekman

This study induces senescence in equine and human cartilage explants by combining mitogenic stimulation with cell cycle arrest, showing increased SA-β-gal activity.

bioRxiv · Mar 5, 2020Cell Biology

Engineered cartilage from human chondrocytes with homozygous knockout of cell cycle inhibitor p21

S. D'Costa, M. J. Rich, B. O. Diekman

This study generates engineered cartilage from human chondrocytes with homozygous p21 knockout, showing increased glycosaminoglycan production and regenerative capacity.

bioRxiv · Aug 9, 2019Bioengineering