Author

W. J. Polacheck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. L. Doherty· 2 shared W. Y. Aw· 2 shared A. H. Cooper· 1 shared A. Har-Zahav· 1 shared A. Hickey· 1 shared A. J. Hickey· 1 shared A. Naji· 1 shared B. Griffith· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

E. L. Doherty

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing Cholangitis

Y. Du, K. Gupta, O. Waisbourd-Zinman, A. Har-Zahav, C. J. Soroka, J. L. Boyer, J. Llewellyn, C. Liu, A. Naji, W. J. Polacheck, R. G. Wells

This paper develops a vascularized bile duct-on-a-chip model to study PSC, showing PSC cholangiocytes exhibit increased inflammation under IL-17A stimulation.

bioRxiv · Mar 2, 2023 · PreprintBioengineering

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

E. L. Doherty, W. Y. Aw, E. C. Warren, M. Hockenberry, G. Krohn, S. D. Howell, B. O. Diekman, W. R. Legant, H. T. Nia, A. Hickey, W. J. Polacheck

The paper shows that COL3A1 mutations alter ECM composition and mechanical properties, affecting endothelial cell migration and suggesting ECM mechanics as a prognostic indicator for vEDS.

bioRxiv · Oct 16, 2022Bioengineering

Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.

W. Y. Aw, C. Cho, H. Wang, A. H. Cooper, E. L. Doherty, D. Rocco, S. A. Huang, S. Kubik, C. P. Whitworth, R. Armstrong, A. J. Hickey, B. Griffith, M. L. Kutys, J. Blatt, W. J. Polacheck

The paper develops a microfluidic model of PIK3CA-driven vascular malformations and identifies dysregulated Rac1/PAK and mTORC1/2 signaling as key factors in lesion formation.

bioRxiv · Sep 3, 2022 · PreprintBioengineering

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

W. Y. Wang, D. Lin, E. H. Jarman, W. J. Polacheck, B. M. Baker

This study investigates how microenvironmental cues balance endothelial cell migration and proliferation to regulate angiogenesis and microvascular function.

bioRxiv · Dec 8, 2019Bioengineering