W. R. Legant

The paper uses correlative single molecule lattice light sheet imaging to study nucleosome dynamics and chromatin environment interactions in live cells, revealing differential diffusion and packing with increasing chromatin density.

The paper introduces smartLLSM, an AI-controlled microscope that switches imaging modes to capture rare cellular events, revealing mitotic dynamics and drug effects with high spatiotemporal resolution.

The paper shows that COL3A1 mutations alter ECM composition and mechanical properties, affecting endothelial cell migration and suggesting ECM mechanics as a prognostic indicator for vEDS.

This study identifies zyxin and non-muscle myosin II as essential for fibroblast durotaxis, while showing Arp2/3 and Rho-kinase are dispensable.

u-track 3D provides a software package for analyzing dense 3D particle dynamics in microscopy data by improving visualization, trajectory validation, and interactive exploration.

This paper introduces DECODE, a deep learning tool that improves single-molecule localization speed and density in SMLM with high accuracy across various imaging conditions.

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

The paper shows that Augmin amplifies long-lived microtubules, directing their plus-ends to kinetochores during spindle assembly in human cells.