B. Orsburn

The carrier proteome limit should be reassessed for each mass analyzer architecture

The study shows that carrier proteome limits vary with mass analyzer type, suggesting that using analyzers with higher linear dynamic range can improve isobaric peptide signal amplification.

Single cell proteomics by mass spectrometry reveals deep epigenetic insight into the actions of an orphan histone deacetylase inhibitor

This study uses single cell proteomics by mass spectrometry to analyze histone post-translational modifications in cancer cells treated with an HDAC inhibitor, identifying 16 PTMs and a previously uncharacterized drug response.

Metabolomic, proteomic and single cell proteomic analysis of cancer cells treated with the KRASG12D inhibitor MRTX1133

This study uses metabolomic, proteomic, and single-cell proteomic analyses to investigate the effects of MRTX1133 on KRASG12D mutant pancreatic cancer cells, revealing distinct drug response populations.

An integrated method for single cell proteomics with simultaneous measurements of intracellular drug concentration implicates new mechanisms for adaptation to KRASG12D inhibitors

This paper develops a method to measure intracellular drug concentrations and proteomic responses in single cells, revealing drug response heterogeneity in KRASG12D inhibitor treatment.

SCP Viz - A universal graphical user interface for single protein analysis in single cell proteomics datasets

SCP Viz is a graphical tool for analyzing single-cell proteomics data, enabling visualization and transformation of protein abundance across cells and subpopulations.

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

This study shows the SWIRM domain of Ada2 tethers the HAT module to SAGA, modulating its deubiquitinating activity.

Non-targeted Screening of Commercial CBD Products in the United States Reveals Common Contamination and Adulteration

This study uses non-targeted screening to reveal common contamination and adulteration in CBD products, including THC variation, over-the-counter drug additives, and trace fluorofentanyl.

In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19

The paper develops an in silico method to identify unique peptides for diagnostic and vaccine targets in viral infections, applying it to SARS-CoV-2 and highlighting 24 peptides as the most diagnostic.

Standard Flow Multiplexed Proteomics (SFloMPro). An Accessible and Cost-Effective Alternative to NanoLC Workflows

This paper introduces SFloMPro, a cost-effective alternative to NanoLC for multiplexed proteomics, showing comparable results with higher reliability and lower cost.

BoxCar Assisted MS Fragmentation (BAMF)

This paper introduces BAMF, a method that improves MS/MS fragmentation by selecting ions directly from BoxCar scans, enabling detection of ions not visible in standard MS1 scans.

The First Publicly Available Annotated Genome for Cannabis plants

The paper describes the first publicly available annotated genome for Cannabis plants, enabling the use of genomic and proteomic tools for research.

Application of Global Metabolomics to the Identification of Complex Counterfeit Medicinal Products

This study uses global metabolomics to identify complex counterfeit medicinal products by analyzing molecular profiles with UHPLC-HRAM-MS/MS and statistical tools.

Assessing a commercial capillary electrophoresis interface (ZipChip) for shotgun proteomic applications

This study evaluates the ZipChip CE-MS system for high-throughput shotgun proteomics, finding it capable of identifying up to 800 unique protein groups in 12 minutes.

Reporter Ion Data Analysis Reduction (R.I.D.A.R) for isobaric proteomics quantification studies

The paper introduces RIDAR, a method to reduce computational load in isobaric proteomics by filtering MS/MS spectra before database searching, achieving an 85% time reduction on a standard desktop.