N. N. Bumpus

Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice

This paper shows that CKB knockout mice have reduced tenofovir activation in brain and liver, with specific mutations impairing CKB's ability to generate the active metabolite TFV-DP.

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

This study shows the SWIRM domain of Ada2 tethers the HAT module to SAGA, modulating its deubiquitinating activity.

EstG is a novel esterase required for cell envelope integrity

This study identifies EstG, a novel esterase in Caulobacter crescentus that protects against cellular stress by acting on cyclic osmoregulated periplasmic glucans rather than the cell wall.

Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells

This paper introduces a single cell proteomics method using trapped ion mobility time-of-flight mass spectrometry, enabling high coverage protein quantification and detection of post-translational modifications in individual human cells.

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

This study identifies TCA cycle metabolites as regulators of topoisomerase II activity and shows their impact on drug sensitivity in vivo.