Nutrient regulation of the islet epigenome controls adaptive insulin secretion
M. Wortham, F. Liu, J. Y. Fleischman, M. Wallace, F. Mulas, N. K. Vinckier, A. R. Harrington, B. R. Cross, J. Chiou, N. A. Patel, Y. Sui, U. S. Jhala, O. S. Shirihai, M. O. Huising, K. J. Gaulton, , M. Sander
This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.
bioRxiv · Aug 21, 2019Physiology