Author

M. O. Huising

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

A. B. Osipovich· 1 shared A. Guillaume· 1 shared A. M. Mawla· 1 shared A. R. Harrington· 1 shared B. R. Cross· 1 shared C. Ellis· 1 shared C. M. J. Chu· 1 shared C. M. Metallo· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperCell Biology

A. B. Osipovich

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Author profile →

5 papers

Recent·Most cited

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

J. Cha, X. Tong, E. M. Walker, T. Dahan, V. Cochrane, S. Ashe, R. Russell, A. B. Osipovich, A. M. Mawla, M. Guo, J.-h. Liu, M. O. Huising, M. A. Magnuson, M. Hebrok, Y. Dor, R. Stein

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

bioRxiv · Oct 20, 2022Cell Biology

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology

Paracrine signaling by pancreatic delta cells determines the glycemic set point in mice

J. L. Huang, S. Lee, M. S. Pourhosseinzadeh, N. Krämer, J. V. Guillen, N. H. Cinque, P. A. Aniceto, S. Koike, M. O. Huising

This study shows that pancreatic delta cells regulate the glycemic set point in mice by modulating beta cell insulin response through paracrine signaling.

bioRxiv · Jun 29, 2022 · PreprintPhysiology

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

M. L. Croze, M. Flisher, A. Guillaume, C. Tremblay, G. M. Noguchi, S. Granziera, K. Vivot, V. C. Castillo, S. A. Campbell, J. Ghislain, M. O. Huising, V. Poitout

This study shows that GPR120 activation in delta cells inhibits somatostatin release, thereby enhancing insulin and glucagon secretion in mice.

bioRxiv · Jul 17, 2020Cell Biology

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

M. Wortham, F. Liu, J. Y. Fleischman, M. Wallace, F. Mulas, N. K. Vinckier, A. R. Harrington, B. R. Cross, J. Chiou, N. A. Patel, Y. Sui, U. S. Jhala, O. S. Shirihai, M. O. Huising, K. J. Gaulton, , M. Sander

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

bioRxiv · Aug 21, 2019Physiology