Author

A. R. Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2

Frequent Co-Authors

M. Sander· 4 shared H. Zhu· 3 shared M. Wortham· 3 shared B. Ramms· 2 shared D. P. Pollow· 2 shared F. Liu· 2 shared K. J. Gaulton· 2 shared O. S. Shirihai· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersPhysiology

M. Sander

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Author profile →

4 papers

Recent·Most cited

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

M. Wortham, B. Ramms, C. Zeng, J. R. Benthuysen, S. Sai, D. P. Pollow, F. Liu, M. Schlichting, A. R. Harrington, B. Liu, T. P. Prakash, E. C. Pirie, H. Zhu, S. Baghdasarian, J. Auwerx, , M. Sander

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

bioRxiv · Feb 24, 2024 · PreprintPhysiology

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

H. Zhu, G. Wang, K.-V. Nguyen-Ngoc, D. Kim, M. Miller, G. Goss, J. Kovsky, A. R. Harrington, D. Saunders, R. Melton, A. C. Powers, S. Preissl, F. M. Spagnoli, K. J. Gaulton, M. Sander

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

bioRxiv · Sep 25, 2022 · PreprintCell Biology

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

B. Ramms, D. P. Pollow, H. Zhu, C. Nora, A. R. Harrington, I. Omar, P. Gordts, M. Wortham, M. Sander

This study shows that systemic LSD1 inhibition reduces obesity-related metabolic issues like NAFLD and improves insulin sensitivity in mice without affecting lean mice.

bioRxiv · Nov 25, 2021Physiology

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

M. Wortham, F. Liu, J. Y. Fleischman, M. Wallace, F. Mulas, N. K. Vinckier, A. R. Harrington, B. R. Cross, J. Chiou, N. A. Patel, Y. Sui, U. S. Jhala, O. S. Shirihai, M. O. Huising, K. J. Gaulton, , M. Sander

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

bioRxiv · Aug 21, 2019Physiology