Author

K. J. Gaulton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. R. Harrington· 2 shared M. Sander· 2 shared A. C. Powers· 1 shared A. Meier· 1 shared B. R. Cross· 1 shared C. M. Metallo· 1 shared C. Tan· 1 shared D. J. McCulley· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

A. R. Harrington

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Author profile →

3 papers

Recent·Most cited

Context-dependent functions of mitochondria protein quality control in lung

L. Xu, C. Tan, J. Barr, N. Talaba, J. Verheyden, J. S. Chin, S. Gaboyan, I. Advani, R. M. Elgamal, K. J. Gaulton, G. Lin, K. Afshar, E. Golts, A. Meier, L. C. Alexander, , X. Sun

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

bioRxiv · Dec 8, 2022 · PreprintCell Biology

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

H. Zhu, G. Wang, K.-V. Nguyen-Ngoc, D. Kim, M. Miller, G. Goss, J. Kovsky, A. R. Harrington, D. Saunders, R. Melton, A. C. Powers, S. Preissl, F. M. Spagnoli, K. J. Gaulton, M. Sander

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

bioRxiv · Sep 25, 2022 · PreprintCell Biology

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

M. Wortham, F. Liu, J. Y. Fleischman, M. Wallace, F. Mulas, N. K. Vinckier, A. R. Harrington, B. R. Cross, J. Chiou, N. A. Patel, Y. Sui, U. S. Jhala, O. S. Shirihai, M. O. Huising, K. J. Gaulton, , M. Sander

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

bioRxiv · Aug 21, 2019Physiology