Author

B. R. Shy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Marson· 2 shared V. S. Vykunta· 2 shared A. E. Dejanov· 1 shared A. Ha· 1 shared C. E. Castro· 1 shared C. R. S. Espinoza· 1 shared D. M. Lopez· 1 shared E. C. Stahl· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. Marson

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3 papers

Recent·Most cited

Engineering an Escherichia coli strain for production of long single-stranded DNA

K. Shen, J. J. Flood, Z. Zhang, A. Ha, B. R. Shy, J. E. Dueber, S. M. Douglas

This paper describes an engineered E. coli strain that produces long single-stranded DNA efficiently, validated for use in genome editing and DNA origami.

bioRxiv · Feb 27, 2024Bioengineering

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

J. Lee, M. E. Robinson, R. Sun, K. Kume, N. Ma, K. N. Cosgun, L. N. Chan, E. Leveille, H. Geng, V. S. Vykunta, B. R. Shy, A. Marson, S. G. Katz, J. Chen, E. Paietta, , M. Mueschen

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

bioRxiv · Mar 13, 2023 · PreprintImmunology

CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells

E. Lin Shiao, W. G. Pfeifer, B. R. Shy, M. S. Doost, E. Chen, V. S. Vykunta, J. R. Hamilton, E. C. Stahl, D. M. Lopez, C. R. S. Espinoza, A. E. Dejanov, R. J. Lew, M. G. Poirer, A. Marson, C. E. Castro, J. A. Doudna

This study delivers DNA nanostructures into human primary cells using CRISPR-Cas9, achieving efficient genomic integration with lower toxicity than dsDNA.

bioRxiv · Nov 8, 2021 · PreprintBioengineering