Author

E. C. Stahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 4 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

J. A. Doudna· 4 shared K. Chen· 2 shared M. H. Kang· 2 shared M. Trinidad· 2 shared R. Allen· 2 shared A. E. Dejanov· 1 shared A. Kimberlin· 1 shared A. Marson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBioengineering

J. A. Doudna

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Author profile →

4 papers

Recent·Most cited

Engineering self-deliverable ribonucleoproteins for genome editing in the brain

K. Chen, E. C. Stahl, M. H. Kang, B. Xu, R. Allen, M. Trinidad, J. A. Doudna

This study engineers self-deliverable CRISPR ribonucleoproteins for efficient genome editing in neural progenitor cells and mouse brain tissue.

bioRxiv · Nov 15, 2023Bioengineering

Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs

E. C. Stahl, J. K. Sabo, M. H. Kang, R. Allen, E. Applegate, S. E. Kim, Y. Kwon, A. Seth, N. Lemus, V. Salinas-Rios, K. Soczek, M. Trinidad, L. T. Vo, C. Jeans, A. Wozniak, , J. A. Doudna

This study demonstrates that minimally immunogenic Cas9 RNPs delivered via convection enhanced delivery can edit mouse striatal neurons with reduced immune responses compared to AAV-delivered Cas9.

bioRxiv · Apr 13, 2023Bioengineering

Improved Genome Editing by an Engineered CRISPR-Cas12a

E. Ma, K. Chen, H. Shi, E. C. Stahl, B. A. Adler, J. Liu, K. Zhou, J. Ye, J. A. Doudna

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

bioRxiv · Sep 2, 2022Biochemistry

CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells

E. Lin Shiao, W. G. Pfeifer, B. R. Shy, M. S. Doost, E. Chen, V. S. Vykunta, J. R. Hamilton, E. C. Stahl, D. M. Lopez, C. R. S. Espinoza, A. E. Dejanov, R. J. Lew, M. G. Poirer, A. Marson, C. E. Castro, J. A. Doudna

This study delivers DNA nanostructures into human primary cells using CRISPR-Cas9, achieving efficient genomic integration with lower toxicity than dsDNA.

bioRxiv · Nov 8, 2021 · PreprintBioengineering