S. M. Douglas

Design principles for accurate folding of DNA origami

The paper establishes design principles for accurate DNA origami folding using thermodynamic modeling and graph-based routing, validated through experimental analysis.

Engineering an Escherichia coli strain for production of long single-stranded DNA

This paper describes an engineered E. coli strain that produces long single-stranded DNA efficiently, validated for use in genome editing and DNA origami.

Tight nanoscale clustering of Fc gamma-receptors using DNA origami promotes phagocytosis

The paper shows that tightly clustering Fc gamma-receptors using DNA origami enhances phagocytosis by increasing receptor phosphorylation and downstream signaling efficiency.

DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation

The paper uses DNA origami to pattern synthetic T cell receptors and shows how spatial arrangement affects signaling sensitivity and kinetics.

Molecular goniometers for single-particle cryo-EM of DNA-binding proteins

The paper introduces molecular goniometers using DNA origami to precisely orient DNA-binding proteins for cryo-EM, achieving a 6.5 Å structure of BurrH.

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

Construction of a novel phagemid to produce custom DNA origami scaffolds

The paper constructs a novel phagemid, pScaf, to produce custom DNA origami scaffolds with a smaller fixed region, enabling greater design flexibility.