B. S. Choudhary

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI

This study identifies a hyper-phosphorylation state in drug-resistant TNBC cells caused by EGFR-to-Src kinase switching, making them vulnerable to EGFR TKI treatment.

GPX4-VIM equates a proliferating DTP state in TNBC subtypes with converged vulnerabilities to autophagy and glutathione inhibition.

The paper identifies a proliferating DTP state in TNBC subtypes that is vulnerable to autophagy and glutathione inhibition, linking GPX4-VIM expression to survival outcomes.