Author

B. Solano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:yeast· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. H. Dekker· 3 shared E. van Veen· 2 shared H. Sanchez· 2 shared J. F. X. Diffley· 2 shared T. van Laar· 2 shared A. L. Perkins· 1 shared A. Woodman· 1 shared C. E. Cameron· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

N. H. Dekker

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3 papers

Recent·Most cited

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

H. Sanchez, Z. Liu, E. van Veen, T. van Laar, B. Solano, J. F. X. Diffley, N. H. Dekker

The paper investigates ORC and MCM dynamics at chromatinized origins in yeast, finding that chromatin reduces MCM mobility while maintaining ORC binding efficiency.

bioRxiv · May 18, 2023Biophysics

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

D. Ramirez Montero, H. Sanchez, E. van Veen, T. van Laar, B. Solano, J. F. X. Diffley, N. H. Dekker

This study reports the first single-molecule activation of CMG reconstituted from purified yeast proteins and quantifies its DNA motion, showing nucleotide binding halts diffusion and enables DNA melting.

bioRxiv · Dec 23, 2022Biophysics

Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses

R. Janissen, A. Woodman, K.-M. Lee, I. Moustafa, F. Fitzgerald, P.-N. Huang, L. Kuijpers, A. L. Perkins, D. A. Harki, J. J. Arnold, B. Solano, S.-R. Shih, C. E. Cameron, N. H. Dekker

This study shows that a ribonucleotide analogue induces copy-back RNA synthesis, a new mechanism to combat RNA viruses by promoting defective viral genomes.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology