Author

A. Woodman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

C. E. Cameron· 4 shared F. G. Alnaji· 2 shared J. Arnold· 2 shared J. J. Arnold· 2 shared K. Bentley· 2 shared K.-M. Lee· 2 shared N. H. Dekker· 2 shared R. Janissen· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

C. E. Cameron

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events.

K. Bentley, F. G. Alnaji, L. Woodford, S. Jones, A. Woodman, D. J. Evans

The paper investigates how imprecise recombinant viruses evolve through fitness-driven recombination and resolution processes, showing that resolution involves repeated recombination events leading to wild-type genomes.

bioRxiv · Jun 1, 2021Microbiology

Generated randomly and selected functionally? The nature of enterovirus recombination

F. G. Alnaji, K. Bentley, A. Pearson, A. Woodman, J. D. Moore, H. Fox, A. Macadam, D. Evans

This study investigates the factors influencing recombination in poliovirus, finding that genome function and fitness, rather than sequence identity or structure, determine the identity of recombinant progeny.

bioRxiv · Sep 29, 2020Microbiology

Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses

R. Janissen, A. Woodman, K.-M. Lee, I. Moustafa, F. Fitzgerald, P.-N. Huang, L. Kuijpers, A. L. Perkins, D. A. Harki, J. J. Arnold, B. Solano, S.-R. Shih, C. E. Cameron, N. H. Dekker

This study shows that a ribonucleotide analogue induces copy-back RNA synthesis, a new mechanism to combat RNA viruses by promoting defective viral genomes.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology

RNA-dependent RNA polymerase speed and fidelity are not the only determinants of the mechanism or efficiency of recombination.

H. Kim, V. D. Ellis, A. Woodman, Y. Zhao, J. Arnold, C. Cameron

This study shows that RdRp speed and fidelity are not the only factors determining recombination efficiency in poliovirus, highlighting additional biochemical properties involved.

Genes · Nov 25, 2019Peer-reviewedMicrobiology

More than efficacy revealed by single-cell analysis of antiviral therapeutics

W. Liu, M. Caglar, Z. Mao, A. Woodman, J. Arnold, C. Wilke, C. E. Cameron

This study uses single-cell analysis to evaluate antiviral therapeutics, revealing efficacy and insights into drug resistance evolution and viral lifecycle impact.

bioRxiv · Apr 12, 2019Microbiology

Predicting Intra- and Intertypic Recombination in Enterovirus 71

A. Woodman, K.-M. Lee, R. Janissen, Y.-N. Gong, S.-R. Shih, N. H. Dekker, C. E. Cameron

This study develops a cell-based assay to investigate recombination in EV-A71, finding that strain-type, RNA diversity, RdRp, and sequence homology influence recombination frequency and mechanism.

bioRxiv · Oct 17, 2018 · PreprintMicrobiology

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

W. Fitzsimmons, R. J. Woods, J. T. McCrone, A. Woodman, J. J. Arnold, M. Yennawar, R. Evans, C. E. Cameron, A. S. Lauring

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

bioRxiv · Apr 27, 2018Microbiology