Author

T. van Laar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:yeast· 3 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

N. H. Dekker· 3 shared B. Solano· 2 shared E. van Veen· 2 shared H. Sanchez· 2 shared J. F. X. Diffley· 2 shared A. Biran· 1 shared A. E. E. Verkennis· 1 shared A. Groth· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

N. H. Dekker

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Author profile →

4 papers

Recent·Most cited

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

H. Sanchez, Z. Liu, E. van Veen, T. van Laar, B. Solano, J. F. X. Diffley, N. H. Dekker

The paper investigates ORC and MCM dynamics at chromatinized origins in yeast, finding that chromatin reduces MCM mobility while maintaining ORC binding efficiency.

bioRxiv · May 18, 2023Biophysics

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

D. Ramirez Montero, H. Sanchez, E. van Veen, T. van Laar, B. Solano, J. F. X. Diffley, N. H. Dekker

This study reports the first single-molecule activation of CMG reconstituted from purified yeast proteins and quantifies its DNA motion, showing nucleotide binding halts diffusion and enables DNA melting.

bioRxiv · Dec 23, 2022Biophysics

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

C. Rouillon, B. V. Eckhardt, L. Kollenstart, F. Gruss, A. E. E. Verkennis, I. Rondeel, P. H. L. Krijger, G. Ricci, A. Biran, T. van Laar, C. M. Delvaux de Fenffe, G. Luppens, P. Albanese, R. A. Scheltema, W. de Laat, , F. Mattiroli

This study shows CAF-1 deposits histones on both DNA strands during replication but uses different mechanisms on leading and lagging strands.

bioRxiv · Oct 14, 2022Biochemistry

SMC complexes can traverse physical roadblocks bigger than their ring size

B. Pradhan, R. Barth, E. Kim, I. F. Davidson, B. Bauer, T. van Laar, W. Yang, J.-K. Ryu, J. van der Torre, J.-M. Peters, C. Dekker

The paper shows that SMC complexes can extrude DNA loops around large DNA-bound obstacles, suggesting a nontopological mechanism for loop extrusion.

bioRxiv · Jul 15, 2021Biophysics