Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes
N. Landon-Brace, B. T. Innes, S. Latour, J. L. Cadavid, I. L. Co, C. Tam, F. Nowlan, S. Drissler, F. Notta, H. W. Jackson, G. D. Bader, A. P. McGuigan
This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.
bioRxiv · Mar 5, 2024 · PreprintCancer Biology