S. Latour

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

The paper investigates the differential roles of CTPS1 and CTPS2 in cell proliferation, finding that CTPS1 is more critical for cell growth than CTPS2.

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays

This paper introduces an automated workflow for generating and analyzing 3D tumor-mimetic microtissues using the SPOT platform, enabling high-throughput screening and single-cell analysis of patient-derived organoids.

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

Multi-omics approach reveals new insights into the gut microbiome of Galleria mellonella (Lepidoptera:Pyralidae) exposed to polyethylene diet

This study uses a multi-omics approach to analyze the gut microbiome of Galleria mellonella fed a polyethylene diet, identifying key bacterial families and potential plastic-degrading enzymes.

CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs

This study compares CD28 and 4-1BB costimulatory domains in CAR-Tregs, finding CD28 better preserves function and survival under tonic signaling.

Stromal cells regulate malignant B-cell spatial organization, survival, and drug response in a new 3D model mimicking lymphoma tumor niche

The paper develops a 3D model of B-cell lymphoma using microfluidic alginate microspheres to study stromal cell interactions and drug response.

Network Analysis Of Inflammatory Bowel Disease Reveals PTPN2 As New Monogenic Cause Of Intestinal Inflammation

The paper uses network analysis to identify PTPN2 as a new monogenic cause of intestinal inflammation by integrating monogenic and polygenic IBD data.

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.