A. P. McGuigan

A cryopreservation strategy for myoblast storage in paper-based scaffolds for inter-laboratory studies of skeletal muscle health

This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

mini-MEndR: A 96-well mixed species assay to co-evaluate human and mouse Pax7+ cell-mediated skeletal muscle repair

The paper introduces a 96-well mini-MEndR assay to co-evaluate human and mouse Pax7+ cell-mediated skeletal muscle repair, demonstrating its utility for drug screening and phenotypic analysis.

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays

This paper introduces an automated workflow for generating and analyzing 3D tumor-mimetic microtissues using the SPOT platform, enabling high-throughput screening and single-cell analysis of patient-derived organoids.

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

A three-dimensional human adipocyte model of fatty acid-induced obesity

This paper develops a 3D in vitro model of human adipocytes to study fatty acid-induced obesity and its associated pathologies.

REVOLVER: a low-cost automated protein purifier based on parallel preparative gravity column workflows

REVOLVER is a low-cost automated protein purification system that enables parallel processing with minimal human intervention, achieving results comparable to manual methods.

Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A Tissue Model to Probe Tumour Phenotypes at Tumour-Stroma Interfaces

GLAnCE is a hydrogel platform that enables real-time observation of CAF-tumour cell interactions at the tumour-stroma interface, revealing interface-specific invasion and EMT gene induction.