Author

H. W. Jackson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

A. Malik· 2 shared D. Schramek· 2 shared J. Wrana· 2 shared K. Teng· 2 shared R. Tsai· 2 shared A. Ayyaz· 1 shared A. Kuttanamkuzhi· 1 shared A. P. McGuigan· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. Malik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

N. Landon-Brace, B. T. Innes, S. Latour, J. L. Cadavid, I. L. Co, C. Tam, F. Nowlan, S. Drissler, F. Notta, H. W. Jackson, G. D. Bader, A. P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

FABP7 Progenitors are a Targetable Metabolic Root in the BRCA1 Breast

C. W. McCloskey, B. Zhang, M. Waas, G. Abazari, F. Vyas, K. Aliar, P. Tharmapalan, A. Kuttanamkuzhi, S. Narala, J. Cruikshank, S. O. P. Hofer, H. W. Jackson, T. Kislinger, H. K. Berman, R. Khokha

This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

D. Dervovic, E. L. Y. Chen, A. Malik, S. Afiuni, J. Boucher, J. M. Berman, K. Teng, A. Ayyaz, Y. Lu, M. Narimatsu, G. Mbamalu, S. Loganathan, S. Martinez, R. Tsai, J.-B. Lee, , D. Schramek

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

bioRxiv · Mar 13, 2022Cancer Biology

Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer

E. Langille, K. N. Al-Zahrani, Z. Ma, A. Malik, S. K. Loganathan, D. Trcka, J. Liu, K. Kozma, R. Tsai, K. Teng, R. Espin, S. Barutcu, T. Nguyen, R. Bremner, H. W. Jackson, , D. Schramek

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

bioRxiv · Oct 22, 2021 · PreprintCancer Biology