G. D. Bader

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

Single-cell and spatial transcriptomics reveals the human liver immunological landscape and myeloid dysfunction in PSC.

This paper uses single-cell and spatial transcriptomics to map the immune landscape of PSC livers, revealing myeloid dysfunction and cytokine-driven inflammation.

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity

This study uses scRNA-seq and snRNA-seq to analyze 73,295 human liver cells, revealing heterogeneity in hepatic stellate cells, cholangiocytes, and interzonal hepatocytes.

Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment

This study examines methylation changes in cell-free DNA of mCRPC patients during androgen-targeting therapy, finding that persistent methylation changes correlate with longer time to clinical progression.