Author

J. L. Cadavid

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Research Focus:clustering· 1

Frequent Co-Authors

A. P. McGuigan· 5 shared S. Latour· 3 shared I. L. Co· 2 shared N. C. Wu· 2 shared N. Landon-Brace· 2 shared N. T. Li· 2 shared R. Cao· 2 shared A. Fomina· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBioengineering

A. P. McGuigan

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5 papers

Recent·Most cited

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

N. Landon-Brace, B. T. Innes, S. Latour, J. L. Cadavid, I. L. Co, C. Tam, F. Nowlan, S. Drissler, F. Notta, H. W. Jackson, G. D. Bader, A. P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

I. L. Co, C. Yu, S. Lamorte, M. T. Ciudad, N. Landon-Brace, J. L. Cadavid, Z. Xia, A. Fomina, M. Nurse, T. L. McGaha, K. R. Campbell, A. P. McGuigan

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

bioRxiv · Jul 13, 2023 · PreprintBioengineering

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays

R. Cao, N. T. Li, J. L. Cadavid, S. Latour, C. M. Tan, A. P. McGuigan

This paper introduces an automated workflow for generating and analyzing 3D tumor-mimetic microtissues using the SPOT platform, enabling high-throughput screening and single-cell analysis of patient-derived organoids.

bioRxiv · Aug 20, 2022Bioengineering

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

N. T. Li, N. C. Wu, R. Cao, J. L. Cadavid, S. Latour, X. Lu, Y. Zhu, M. Mijalkovic, R. Roozitalab, A. P. McGuigan

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

bioRxiv · Aug 14, 2022Bioengineering

Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A Tissue Model to Probe Tumour Phenotypes at Tumour-Stroma Interfaces

E. D'Arcangelo, N. C. Wu, T. Chen, A. Shahaj, J. L. Cadavid, L. Huang, L. Ailles, A. P. McGuigan

GLAnCE is a hydrogel platform that enables real-time observation of CAF-tumour cell interactions at the tumour-stroma interface, revealing interface-specific invasion and EMT gene induction.

bioRxiv · Sep 30, 2019Bioengineering