The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells
X. Liao, W. Li, A. Li, B. K. Rajendran, J. Ren, H. Zhou, D. Calderwood, B. Turk, W. Tang, Y. Liu, D. Wu
This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.
bioRxiv · Nov 16, 2022 · PreprintImmunology