The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis
T. Demoulins, M. Bruegger, B. Zumhehr, B. Oliveira Esteves, K. Mehinagic, A. Fahmi, L. Borcard, A. Taddeo, H. Posthaus, C. Benarafa, N. Ruggli, M. P. Alves
This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.
bioRxiv · Aug 14, 2020Immunology