Author

H. Posthaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

N. Ruggli· 4 shared K. Mehinagic· 3 shared A. Kratzel· 2 shared A. Summerfield· 2 shared B. Oliveira Esteves· 2 shared C. Benarafa· 2 shared C. Gurtner· 2 shared H. Stalder· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

N. Ruggli

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

E. Radulovic, K. Mehinagic, T. Wüthrich, M. Hilty, H. Posthaus, A. Summerfield, N. Ruggli, C. Benarafa

This study shows that the immunological and hygienic status of pigs affects the severity of African swine fever, with SPF pigs showing different immune responses compared to farm-raised pigs.

bioRxiv · Apr 19, 2022Microbiology

Cryo-EM structure of the octameric pore of Clostridium perfringens β-toxin

J. Bruggisser, I. Iacovache, S. C. Musson, M. T. Degiacomi, H. Posthaus, B. Zuber

This paper presents the cryo-EM structure of the octameric pore of Clostridium perfringens β-toxin, revealing its unique architecture and potential applications in nanotechnology.

bioRxiv · Nov 23, 2021Biophysics

Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus

M. Gultom, A. Kratzel, J. Portmann, H. Stalder, A. C. Baetzner, H. Gantenbein, C. Gurtner, N. Ebert, H. Posthaus, P. Zanolari, S. Pfaender, V. Thiel, R. Dijkman

This study establishes camelid airway epithelial cell cultures to study MERS-CoV infection and replication, showing divergent tropism and interferon inhibition.

bioRxiv · Nov 10, 2021Microbiology

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

M. Brugger, T. Demoulins, G. T. Barut, B. Zumkehr, B. Oliveira Esteves, K. Mehinagic, Q. Haas, A. Schogler, M.-A. Rameix-Welti, J.-F. Eleouet, U. Moehrlen, T. Marti, R. Schmid, A. Summerfield, H. Posthaus, , M. P. Alves

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

bioRxiv · May 12, 2021Microbiology

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

M. Gultom, M. Licheri, L. Laloli, M. Wider, M. Straessle, S. Steiner, A. Kratzel, T. T. N. Thao, H. Stalder, J. Portmann, M. Holwerda, P. V'kovski, N. Ebert, N. Stokar - Regenscheit, C. Gurtner, , R. Dijkman

This study assesses the susceptibility of airway epithelial cell cultures from various animals to SARS-CoV-2, finding efficient replication only in monkey and cat models.

bioRxiv · Nov 10, 2020 · PreprintMicrobiology

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

T. Demoulins, M. Bruegger, B. Zumhehr, B. Oliveira Esteves, K. Mehinagic, A. Fahmi, L. Borcard, A. Taddeo, H. Posthaus, C. Benarafa, N. Ruggli, M. P. Alves

This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.

bioRxiv · Aug 14, 2020Immunology

Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

J. Jores, L. Ma, P. Ssajjakambwe, E. Schieck, A. M. Liljander, S. Chandran, M. H. Stoffel, V. L. Cippa, Y. Arfi, N. Asad-Garcia, L. Falquet, P. Sirand-Pugnet, A. Blanchard, C. Lartigue, H. Posthaus, , S. Vashee

This paper attenuates a highly virulent Mycoplasma strain by deleting non-essential genes and demonstrates its safety in vivo using a goat model.

bioRxiv · Jan 10, 2019Microbiology