N. Ruggli

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

This study shows that serial passaging of JEV in pigs leads to fitness adaptations and amino acid changes, but not increased direct transmission.

Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids

This study shows MPXV spreads cell-to-cell in human neural organoids, causing neuronal death and neuritic bead formation, and identifies tecovirimat as effective in reducing viral load.

The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

This study shows that the immunological and hygienic status of pigs affects the severity of African swine fever, with SPF pigs showing different immune responses compared to farm-raised pigs.

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

This study assesses the susceptibility of airway epithelial cell cultures from various animals to SARS-CoV-2, finding efficient replication only in monkey and cat models.

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.