Author

C. Benarafa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Taddeo· 5 shared V. Thiel· 4 shared B. Hoffmann· 3 shared C. Devisme· 3 shared D. Hoffmann· 3 shared J. N. Kelly· 3 shared L. Thomann· 3 shared L. Ulrich· 3 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

A. Taddeo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2

A. Taddeo, I. Berenguer Veiga, C. Devisme, R. Boss, P. Plattet, S. Weigang, G. Kochs, V. Thiel, C. Benarafa, G. Zimmer

This study shows that VSV-vectored spike protein vaccines induce protective immunity when trans-complemented with VSV glycoprotein, but do not achieve sterilizing immunity against SARS-CoV-2.

bioRxiv · Jun 14, 2022 · PreprintImmunology

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

T. Barut, N. J. Halwe, A. Taddeo, J. N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B. S. Trueeb, B. Hoffmann, I. B. Veiga, N. F. G. Leborgne, E. A. Moreira, A. Breithaupt, , V. Thiel

This study shows the spike gene determines replication, pathogenicity, and immune evasion of SARS-CoV-2 Omicron-BA.1 compared to Delta in cell cultures and animal models.

bioRxiv · Apr 28, 2022Microbiology

The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

E. Radulovic, K. Mehinagic, T. Wüthrich, M. Hilty, H. Posthaus, A. Summerfield, N. Ruggli, C. Benarafa

This study shows that the immunological and hygienic status of pigs affects the severity of African swine fever, with SPF pigs showing different immune responses compared to farm-raised pigs.

bioRxiv · Apr 19, 2022Microbiology

Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models

L. Ulrich, N. J. Halwe, A. Taddeo, N. Ebert, J. Schön, C. Devisme, B. S. Trüeb, B. Hoffmann, M. Wider, M. Bekliz, M. Essaidi-Laziosi, M. L. Schmidt, D. Niemeyer, V. M. Corman, A. Kraft, , C. Benarafa

The paper compares the fitness of SARS-CoV-2 variants B.1.1.7 and B.1.351 in animal models, finding B.1.1.7 has a fitness advantage in ferrets and mice but not in hamsters.

bioRxiv · Jun 28, 2021Microbiology

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

B. Zhou, T. T. N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, F. Labroussaa, A. Pohlmann, J. King, J. Portmann, N. J. Halwe, L. Ulrich, B. S. Trueb, J. N. Kelly, X. Fan, B. Hoffmann, , M. Beer

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

bioRxiv · Oct 27, 2020Microbiology

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

T. Demoulins, M. Bruegger, B. Zumhehr, B. Oliveira Esteves, K. Mehinagic, A. Fahmi, L. Borcard, A. Taddeo, H. Posthaus, C. Benarafa, N. Ruggli, M. P. Alves

This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.

bioRxiv · Aug 14, 2020Immunology