Author

Babet O. Springer

Amsterdam University Medical Centers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Christian BlankiD· 2 shared Georgia ClaytoniD· 2 shared Magalí B. CoccimiglioiD· 2 shared Mariëtte LabotsiD· 2 shared S C M A WijneniD· 2 shared Tanja D. de GruijliD· 2 shared Yvette van KooykiD· 2 shared Aurélie GuislainiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Christian BlankORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PAIR-Scan: Single-step identification of highly potent TCR-neoantigen pairs through library-on-library screening

Marius Messemaker, Connor A. Richterich, Jule Wenner, Yiting Ma, Živa Moravec, Rhianne Voogd, Maike Mussmann, Sam de Paauw, Bjørn P. Y. Kwee, Jeroen Geerligs, Ben Morris, Yael Winkler, Babet O. Springer, Floris van den Brekel, Jos H. M. Urbanus, , Ton N. Schumacher

PAIR-Scan identifies potent TCR-neoantigen pairs from tumor samples through library-on-library screening, enabling efficient analysis of T cell reactivity.

bioRxiv · Sep 15, 2026 · PreprintImmunology

SIGLEC1 FACILITATES MACROPHAGE-CD8+ T CELL INTERACTIONS AND CORRELATES WITH CANCER IMMUNOTHERAPY RESPONSE

Sofía Ibáñez Molero, Magalí B. Coccimiglio, Babet O. Springer, Megan Bowien de Ruiter, Georgia Clayton, S C M A Wijnen, Christian Blank, Mariëtte Labots, Tanja D. de Gruijl, Yvette van Kooyk

This study identifies SIGLEC1 as a mediator of macrophage-CD8+ T cell interactions in melanoma and shows its correlation with response to immune checkpoint blockade.

bioRxiv · Jul 15, 2026 · PreprintImmunology

CMAS dampens anti-tumor immunity and associates with response to neoadjuvant immunotherapy in melanoma

Magalí B. Coccimiglio, Sofia Ibáñez‐Molero, Babet O. Springer, Laura J. W. Kruijssen, Georgia Clayton, Reece Davison, Tao Zhang, S C M A Wijnen, Ernesto Rodríguez, Katarzyna Olesek, S. Veenstra, Thomas van den Brekel, Eleonora Nardini, Joelle van Elk, Eelco D. Keuning, , Yvette van Kooyk

The paper shows CMAS in melanoma cells correlates with poor survival and reduced response to immunotherapy by altering tumor-immune interactions.

bioRxiv · Apr 29, 2026 · PreprintCancer Biology