The paper develops a validated TCR-pMHC database (TCRvdb) by assessing VDJdb entries with a high-throughput platform, finding only 50% of claims are functionally confirmed.

Immunity · Oct 1, 2026Peer-reviewedImmunology

PAIR-Scan: Single-step identification of highly potent TCR-neoantigen pairs through library-on-library screening

Marius Messemaker, Connor A. Richterich, Jule Wenner, Yiting Ma, Živa Moravec, Rhianne Voogd, Maike Mussmann, Sam de Paauw, Bjørn P. Y. Kwee, Jeroen Geerligs, Ben Morris, Yael Winkler, Babet O. Springer, Floris van den Brekel, Jos H. M. Urbanus, , Ton N. Schumacher

PAIR-Scan identifies potent TCR-neoantigen pairs from tumor samples through library-on-library screening, enabling efficient analysis of T cell reactivity.

bioRxiv · Sep 15, 2026 · PreprintImmunology

Proteomics of human cancer-associated T cells identifies regulators of T cell functionality

Kaspar Bresser, Žan Hozjan, Nila H. Servaas, Suzan Stelloo, Cornelia G. Spruijt, Maia Nestor Martin, Aurélie Guislain, Nandhini Kanagasabesan, Stijn F.K. Kneefel, Arie Johan Hoogendijk, Carmen van der Zwaan, Živa Moravec, Rhianne Voogd, Marja Nieuwland, Jessica Sieljes, , Monika C. Wolkers

The paper identifies proteomic regulators of T cell functionality in cancer using proteomic and transcriptomic profiling of tumor-infiltrating T cells.

bioRxiv · Aug 23, 2026 · PreprintImmunology