Ben Morris

A functionally validated TCR-pMHC database for TCR specificity model development

The paper develops a validated TCR-pMHC database (TCRvdb) by assessing VDJdb entries with a high-throughput platform, finding only 50% of claims are functionally confirmed.

PAIR-Scan: Single-step identification of highly potent TCR-neoantigen pairs through library-on-library screening

PAIR-Scan identifies potent TCR-neoantigen pairs from tumor samples through library-on-library screening, enabling efficient analysis of T cell reactivity.

Condensate screening identifies YM155 as β-catenin condensate inhibitor in colorectal cancer

The paper identifies YM155 as a β-catenin condensate inhibitor using a NECO screening platform, showing its anti-proliferative effect on WNT-driven colorectal cancer organoids.

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

The paper investigates the molecular and genomic effects of a global DNA damage tolerance defect, identifying type 3 deletions as a mutational signature of replication stress.

Widespread chromatin context-dependencies ofDNA double-strand break repair proteins

A multiplexed screen reveals how dozens of proteins sense the local chromatin context to tune the balance between two DNA repair pathways.

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

This study identifies 67 epigenetic drugs that modulate CRISPR-Cas9 editing efficiency and repair outcomes based on chromatin context in human cells.

Performance of large scale pooled CRISPR screens is dependent on Cas9 expression levels

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

The paper measures how chromatin context influences the balance between DNA repair pathways after Cas9-induced breaks in over 1,000 genomic locations.