Tanja D. de Gruijl

This study shows that reducing sialylation in melanoma enhances classical pathway-mediated complement activation, increasing C3 opsonization and membrane attack complex formation.

This study identifies SIGLEC1 as a mediator of macrophage-CD8+ T cell interactions in melanoma and shows its correlation with response to immune checkpoint blockade.

The paper shows CMAS in melanoma cells correlates with poor survival and reduced response to immunotherapy by altering tumor-immune interactions.

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.