This study identifies SIGLEC1 as a mediator of macrophage-CD8+ T cell interactions in melanoma and shows its correlation with response to immune checkpoint blockade.

bioRxiv · Jul 15, 2026 · PreprintImmunology

CMAS dampens anti-tumor immunity and associates with response to neoadjuvant immunotherapy in melanoma

Magalí B. Coccimiglio, Sofia Ibáñez‐Molero, Babet O. Springer, Laura J. W. Kruijssen, Georgia Clayton, Reece Davison, Tao Zhang, S C M A Wijnen, Ernesto Rodríguez, Katarzyna Olesek, S. Veenstra, Thomas van den Brekel, Eleonora Nardini, Joelle van Elk, Eelco D. Keuning, , Yvette van Kooyk

The paper shows CMAS in melanoma cells correlates with poor survival and reduced response to immunotherapy by altering tumor-immune interactions.

bioRxiv · Apr 29, 2026 · PreprintCancer Biology

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active phosphokinases

Robin Beekhof, Carolien van Alphen, Alex A. Henneman, Jaco C. Knol, Thang V. Pham, Frank Rolfs, Mariëtte Labots, Evan Henneberry, Tessa Y. S. Le Large, Richard R. de Haas, Sander R. Piersma, Valentina Vurchio, Andrea Bertotti, Livio Trusolino, Henk M.W. Verheul, Connie R. Jiménez

INKA identifies active phosphokinases in cancer by integrating kinase and substrate phosphorylation data from phosphoproteomics.

Molecular Systems Biology · Apr 1, 2019Peer-reviewedSystems Biology