Pierre Bruhns

The paper shows that variant-specific spike conformational dynamics influence memory B cell recruitment and antibody responses during vaccination.

This study shows that agalactosylated IgG N-glycans in RA reduce neutrophilic inflammation by decreasing FcγR binding and downstream signaling, suggesting they may act as a compensatory anti-inflammatory mechanism.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.