Transmitted alpha-synuclein extracellular vesicles downregulate axonal flux of retrograde carriers in recipient neurons
Barbara E Duda, Saber H. Saber, Vanessa Lanoue, Adekunle T. Bademosi, Rachel S. Gormal, Tristan P. Wallis, Alex J. McCann, Yara Abosnwber, Justin John Cooper-White, Patrik Verstreken, Frédéric A. Meunier
This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.
bioRxiv · Sep 22, 2025 · PreprintNeuroscience