Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation
Juncal Fernández‐Orth, Cansu Koyunlar, Julia Miriam Weiss, Emanuele Gioacchino, Hans W. J. de Looper, Geoffroy Andrieux, Mariëtte ter Borg, Joke Zink, Irene González-Menéndez, Remco Michiel Hoogenboezem, Baris Yigit, Kirsten J. Gussinklo, Roger Mulet‐Lazaro, Charlotte Wantzen, Sophie Pfeiffer, , Emma de Pater
This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.
Blood Advances · Mar 26, 2025Peer-reviewedCell Biology