Emma de Pater

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

This study shows that Gata2 regulates Gfi1b to control endothelial-to-hematopoietic transition and HSPC maturation, with reduced Gata2 leading to impaired hematopoietic programming.

This study shows that Gpr56 and Gpr97 have redundant roles in mammalian hematopoietic cell development and differentiation, with Gpr97 compensating for Gpr56 loss in zebrafish and mouse models.

The paper studies macrophage development in zebrafish lacking CSF1R, finding developmental arrest and the emergence of Csf1r-independent metaphocytes.

This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.