A PP2A-Integrator complex fine-tunes transcription by opposing CDK9
Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah R. Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod John Sandow, Zheng Fan, Benjamin J. Blyth, Victoria M. McLeod, Joseph H.A. Vissers, , Ricky W. Johnstone
The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.
Cell · May 17, 2021Peer-reviewedGenomics