Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
Anchi S. Chann, Mirren Charnley, Lucas M. Newton, Andrea Newbold, Florian Wiede, Tony Tiganis, Patrick Orson Humbert, Ricky W. Johnstone, Sarah May Russell
This study uses histone deacetylase inhibition to reveal a new stage in T cell β-selection, showing how CD28, CD5, Lef1, and CD2 coordinate to regulate the checkpoint.
Life Science Alliance · Oct 25, 2022Peer-reviewedDevelopmental Biology