Author

Sarah R. Offley

The Wistar InstituteORCID 0000-0002-4902-333XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Sarah A. WelshiD· 2 shared Alessandro GardiniiD· 1 shared Alyxandra T. Curtis· 1 shared Andrea NewboldiD· 1 shared Ben P. Martin· 1 shared Benjamin J. BlythiD· 1 shared Bruno Calabretta· 1 shared Chiara ScopaiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Sarah A. WelshORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah R. Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W.E. Santen, Marco Trizzino

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.

Nature Communications · Nov 9, 2021Peer-reviewedGenomics

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah R. Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod John Sandow, Zheng Fan, Benjamin J. Blyth, Victoria M. McLeod, Joseph H.A. Vissers, , Ricky W. Johnstone

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.

Cell · May 17, 2021Peer-reviewedGenomics